AR-A 014418

Name: AR-A 014418
Brand: Tocris Bioscience
SKU: 3966

Tocris Bioscience, part of Bio-Techne | Catalog # 3966

Citations (8)

COA / SDS

Selective GSK-3 inhibitor

Key Product Details

Description:	Selective GSK-3 inhibitor
Chemical Name:	N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea
Purity:	≥98% (HPLC)
Molecular Weight:	308.31

View Full Technical Details for AR-A 014418

Technical Data
Citations

Biological Activity for AR-A 014418

AR-A 014418 is a selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC₅₀ = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC₅₀ values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries for AR-A 014418

AR-A 014418 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for AR-A 014418

M. Wt	308.31
Formula	C₁₂H₁₂N₄O₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	487021-52-3
PubChem ID	448014
InChi Key	YAEMHJKFIIIULI-UHFFFAOYSA-N
Smiles	O=C(NCC2=CC=C(OC)C=C2)NC1=NC=C([N+]([O-])=O)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AR-A 014418

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	30.83	100
	ethanol	1.54	5

Preparing Stock Solutions for AR-A 014418

The following data is based on the product molecular weight 308.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.24 mL	16.22 mL	32.43 mL
5 mM	0.65 mL	3.24 mL	6.49 mL
10 mM	0.32 mL	1.62 mL	3.24 mL
50 mM	0.06 mL	0.32 mL	0.65 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for AR-A 014418

References are publications that support the biological activity of the product.

Bhat Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. J.Biol.Chem. 2003 PMID: 12928438
Gould AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test. Int.J.Neuropsychopharmacol. 2004 PMID: 15315719
Bhat and Budd GSK3β signalling: casting a wide net in Alzheimer's disease. Neurosignals 2002 PMID: 12566926