AP 14145 hydrochloride

Name: AP 14145 hydrochloride
Brand: Tocris Bioscience
SKU: 6481

Tocris Bioscience, part of Bio-Techne | Catalog # 6481

COA / SDS

Negative allosteric modulator of KCa2 (SK) channels

Key Product Details

Description:	Negative allosteric modulator of K_Ca2 (SK) channels
Chemical Name:	N-[2-[[(1R)-1-[3-(Trifluoromethyl)phenyl]ethyl]amino]-1H-benzimidazol-7-yl]acetamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	398.81

View Full Technical Details for AP 14145 hydrochloride

Technical Data
Citations

Biological Activity for AP 14145 hydrochloride

AP 14145 hydrochloride is a K_Ca2 (small conductance Ca²⁺-activated potassium) channel negative allosteric modulator (IC₅₀ = 1.1 μM). Increases the EC₅₀ of Ca²⁺ on K_Ca2.3 channels by ~3-fold. Prolongs atrial effective refractory period (AERP) in rats. Reduces atrial fibrillation (AF) duration and prolongs atrial refractoriness without affecting ventricular refractory period in an animal AF model.

Technical Data for AP 14145 hydrochloride

M. Wt	398.81
Formula	C₁₈H₁₇F₃N₄O.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2387505-59-9
InChi Key	KGIUXIYNTCVBST-HNCPQSOCSA-N
Smiles	C[C@H](C1=CC(C(F)(F)F)=CC=C1)NC2=NC3=CC=CC(NC(C)=O)=C3N2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AP 14145 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	39.88	100
	ethanol	39.88	100

Preparing Stock Solutions for AP 14145 hydrochloride

The following data is based on the product molecular weight 398.81.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.51 mL	12.54 mL	25.07 mL
5 mM	0.50 mL	2.51 mL	5.01 mL
10 mM	0.25 mL	1.25 mL	2.51 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for AP 14145 hydrochloride

References are publications that support the biological activity of the product.

Simó-Vicens A new negative allosteric modulator, AP14145, for the study of small conductance calcium-activated potassium (K_Ca2) channels. Br.J.Pharmacol. 2017 PMID: 28925012
Diness Termination of vernakalant-resistant atrial fibrillation by inhibition of small-conductance Ca²⁺-activated K⁺ channels in pigs. Circ.Arrhythm.Electrophysiol. 2017 PMID: 29018164