ANR 94

Tocris Bioscience, part of Bio-Techne | Catalog # 3937

COA / SDS

Adenosine A2A antagonist

Key Product Details

Description:	Adenosine A_2Aantagonist
Chemical Name:	8-Ethoxy-9-ethyl-9H-purin-6-amine
Purity:	≥98% (HPLC)
Molecular Weight:	207.23

View Full Technical Details for ANR 94

Technical Data
Citations

Biological Activity for ANR 94

ANR 94 is an adenosine A_2A receptor (AA_2AR) antagonist (K_i values are 643 and 46 nM for rat and human AA_2ARs respectively). Most active AA_2AR antagonist for human receptors. Displays activity in the treatment of Parkinson's disease in vivo; improves parkinsonian motor deficits and tremors. Exhibits neuroprotective and anti-inflammatory effects.

Compound Libraries for ANR 94

ANR 94 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ANR 94

M. Wt	207.23
Formula	C₉H₁₃N₅O
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	634924-89-3
PubChem ID	11805896
InChi Key	QUGDTMONBLMLLD-UHFFFAOYSA-N
Smiles	CCN2C1=NC=NC(N)=C1N=C2OCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ANR 94

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	10.36	50
	ethanol	20.72	100

Preparing Stock Solutions for ANR 94

The following data is based on the product molecular weight 207.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.83 mL	24.13 mL	48.26 mL
5 mM	0.97 mL	4.83 mL	9.65 mL
10 mM	0.48 mL	2.41 mL	4.83 mL
50 mM	0.10 mL	0.48 mL	0.97 mL

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Reconstitution Calculator

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References for ANR 94

References are publications that support the biological activity of the product.

Volpini Adenosine A_2A receptor antagonists: New 8-substituted 9-ethyladenines as tools for in vivo rat models of Parkinson's disease. Chem.Med.Chem. 2010 PMID: 19343763
Pinna A new ethyladenine antagonist of adenosine A_2A receptors: Behavioral and biochemical characterization as an antiparkinsonian drug. Neuropharmacology 2010 PMID: 19951715