ANR 94
Tocris Bioscience, part of Bio-Techne | Catalog # 3937
Adenosine A2A antagonist
Key Product Details
Description
Adenosine A2A antagonist
Product Description
ANR 94 is an adenosine A2A receptor (AA2AR) antagonist (Ki values are 643 and 46 nM for rat and human AA2ARs respectively). Most active AA2AR antagonist for human receptors. Displays activity in the treatment of Parkinson's disease in vivo; improves parkinsonian motor deficits and tremors. Exhibits neuroprotective and anti-inflammatory effects.Product Specifications
Molecular Weight
207.23
Formula
C9H13N5O
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
8-Ethoxy-9-ethyl-9H-purin-6-amine
CAS Number
634924-89-3
PubChem ID
11805896
InChI Key
QUGDTMONBLMLLD-UHFFFAOYSA-N
SMILES
CCN2C1=NC=NC(N)=C1N=C2OCC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.36 | 50 | |
| Ethanol | 20.72 | 100 |
Preparing Stock Solutions
for ANR 94
The following data is based on the product molecular weight 207.23
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.83 mL | 24.13 mL | 48.26 mL |
| 5 mM | 0.97 mL | 4.83 mL | 9.65 mL |
| 10 mM | 0.48 mL | 2.41 mL | 4.83 mL |
| 50 mM | 0.10 mL | 0.48 mL | 0.97 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Volpini Adenosine A2A receptor antagonists: New 8-substituted 9-ethyladenines as tools for in vivo rat models of Parkinson's disease. Chem.Med.Chem. 2010 PMID: 19343763
- Pinna A new ethyladenine antagonist of adenosine A2A receptors: Behavioral and biochemical characterization as an antiparkinsonian drug. Neuropharmacology 2010 PMID: 19951715
Product Specific Notices for ANR 94
For research use only
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