Angiopep-2-Cys

Name: Angiopep-2-Cys
Brand: Tocris Bioscience
SKU: 8902

Tocris Bioscience, part of Bio-Techne | Catalog # 8902

COA / SDS

Binds to LRP1 and facilitates receptor-mediated transcytosis of cargo across the BBB

Key Product Details

Description:	Binds to LRP1 and facilitates receptor-mediated transcytosis of cargo across the BBB
Purity:	≥95% (HPLC)
Molecular Weight:	2404.64

View Full Technical Details for Angiopep-2-Cys

Technical Data
Citations

Biological Activity for Angiopep-2-Cys

Angiopep-2-Cys is a synthetic peptide able to specifically interact with low-density lipoprotein receptor-related protein 1 (LRP1) receptors present on brain endothelial cells and neurons. Angiopep-2-Cys is a conjugate of Angiopep-2 (Cat. No. 8828) and Cystein, and can be used to functionalize LNPs via thiol-maleimide click chemistry to target LRP1 receptors present on blood-brain barrier (BBB). mRNA LNPs functionalized with Angiopep-2-Cys shows improved transfection efficiency in cultured brain endothelial and neuronal cells, and in vivo, after systemic administration in mice.

Technical Data for Angiopep-2-Cys

M. Wt	2404.64
Formula	C₁₀₇H₁₅₄N₃₀O₃₂S
Single Letter Sequence	TFFYGGSRGKRNNFKTEEYC
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	906480-09-9
PubChem ID	170836226
InChi Key	NTEVJSCQHIRPSH-ZYRNEBAYSA-N
Smiles	O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC3=CC=C(C=C3)O)C(NCC(NCC(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CS)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Angiopep-2-Cys

Solubility

Soluble to 1mg/ml in water

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References for Angiopep-2-Cys

References are publications that support the biological activity of the product.

Han Peptide-functionalized lipid nanoparticles for targeted systemic mRNA delivery to the brain. Nano Lett. 2025 PMID: 39688915

Product Documents for Angiopep-2-Cys

COA

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service.