Anandamide

Name: Anandamide
Brand: Tocris Bioscience
SKU: 1339
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1339

(2)

Citations (249)

COA / SDS

Endogenous and non-selective CB agonist

Key Product Details

Description:	Endogenous and non-selective CB agonist
Alternative Names:	Arachidonylethanolamide,AEA
Chemical Name:	N-(2-Hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Purity:	≥98% (HPLC)
Molecular Weight:	347.54

View Full Technical Details for Anandamide

Technical Data
Citations / Reviews (2)

Biological Activity for Anandamide

Anandamide is an endogenous cannabinoid and TRPV1 receptor agonist (K_i values are 89 and 371 nM at CB₁ and CB₂ receptors respectively; EC₅₀ values are 18, 31 and 27 nM at GPR55, CB₁ and CB₂ respectively; pK_i = 5.68 for rTRPV1). Also blocks TNF-α-induced NF-κB activation via direct inhibition of IKK.

Deuterated analog also available.

Technical Data for Anandamide

M. Wt	347.54
Formula	C₂₂H₃₇NO₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	94421-68-8
PubChem ID	5281969
InChi Key	LGEQQWMQCRIYKG-DOFZRALJSA-N
Smiles	O=C(NCCO)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Anandamide

Solubility

Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)

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References for Anandamide

References are publications that support the biological activity of the product.

Ellermann Endocannabinoids inhibit the induction of virulence in enteric pathogens. Cell 2020 PMID: 33031742
Sancho Anandamide inhibits nuclear factor-κB activation through a cannabinoid receptor-independent pathway. Mol.Pharmacol. 2003 PMID: 12527815
Ryberg The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 2007 PMID: 17876302
Ross Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens. Br.J.Pharmacol. 2001 PMID: 11159715
Pertwee Pharmacology of cannabinoid receptor ligands. Curr.Med.Chem. 1999 PMID: 10469884
Devane Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 1992 PMID: 1470919