Amylin

Name: Amylin
Brand: Tocris Bioscience
SKU: 3418

Tocris Bioscience, part of Bio-Techne | Catalog # 3418

Citations (21)

COA / SDS

Endogenous peptide agonist for amylin, calcitonin, CGRP and adrenomedullin receptors

Key Product Details

Description:	Endogenous peptide agonist for amylin, calcitonin, CGRP and adrenomedullin receptors
Purity:	≥95% (HPLC)
Molecular Weight:	3903.33

View Full Technical Details for Amylin

Technical Data
Citations

Biological Activity for Amylin

Amylin is an endogenous peptide agonist for amylin, calcitonin, CGRP and adrenomedullin receptors. Inhibits glucagon secretion, delays gastric emptying and acts as a satiety agent. Displays glucose lowering effects in vivo.

Technical Data for Amylin

M. Wt	3903.33
Formula	C₁₆₅H₂₆₁N₅₁O₅₅S₂
Single Letter Sequence	KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY (Modifications: Tyr-37 = C-terminal amide, Disulfide bridge: 2-7)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	122384-88-7
PubChem ID	16132430
InChi Key	PLOPBXQQPZYQFA-AXPWDRQUSA-N
Smiles	[H]N[C@@H](CCCCN)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC1=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Amylin

Solubility

Soluble to 10mg/ml in DMSO

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References for Amylin

References are publications that support the biological activity of the product.

Schmitz Amylin agonists: a novel approach in the treatment of diabetes. Diabetes 2004 PMID: 15561917
Hoogwerf Pramlintide, the synthetic analogue of amylin: physiology, pathophysiology, and effects on glycemic control, body weight, and selected biomarkers of vascular risk. Vasc.Health Risk Manag. 2008 PMID: 18561511
Castillo Amylin/islet polypeptide: biochemistry, physiology, patho-physiology. Diabete Metab. 1995 PMID: 7781840