Amthamine dihydrobromide
Tocris Bioscience, part of Bio-Techne | Catalog # 0668
Highly selective standard H2 agonist
Discontinued Product
0668 has been discontinued.
View all Histamine H2 Receptor Agonists products.
Key Product Details
Description
Highly selective standard H2 agonist
Product Description
Amthamine dihydrobromide is a highly selective H2 agonist, slightly more potent than histamine itself. Only a weak antagonist at H3 and has no activity at H1 receptors. Induces vasodilation of cerebral arteries and decreases myogenic tone in vitro.Product Specifications
Molecular Weight
319.06
Formula
C6H11N3S.2HBr
Storage
Desiccate at -20°C
Purity
≥99% (HPLC)
Chemical Name
2-Amino-5-(2-aminoethyl)-4-methylthiazole dihydrobromide
CAS Number
142457-00-9
PubChem ID
16218912
InChI Key
XFXNNOPUDSFVJE-UHFFFAOYSA-N
SMILES
Br.Br.CC1=C(CCN)SC(N)=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 31.91 | 100 |
Preparing Stock Solutions
for Amthamine dihydrobromide
The following data is based on the product molecular weight 319.06
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.13 mL | 15.67 mL | 31.34 mL |
| 5 mM | 0.63 mL | 3.13 mL | 6.27 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.13 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Poli In vitro cardiac pharmacology of the new histamine H2 receptor agonist amthamine; comparisons with histamine and dimaprit. Agents Actions 1993 PMID: 8147269
- Eriks Histamine H2-receptor agonists. Synthesis, in vitro pharmacology, and qualitative structure-activity relationships of substituted 4- and 5-(2-aminoethyl)thiazole. J.Med.Chem. 1992 PMID: 1507209
- Jarajapu Histamine decreases myogenic tone in rat cerebral arteries by H2-receptor-mediated Kv channel activation, independent of endothelium and cyclic AMP. Eur.J.Pharmacol. 2006 PMID: 16920098
- Coruzzi The new potent and selective histamine H2 receptor agonist amthamine as a tool to study gastric secretion. Naunyn Schmiedebergs Arch.Pharmacol. 1993 PMID: 8377843
Product Specific Notices for Amthamine dihydrobromide
For research use only
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