AMP PNP
Tocris Bioscience, part of Bio-Techne | Catalog # 6086
Kir6 blocker; non-hydrolyzable AMP analog
Key Product Details
Description
Kir6 blocker; non-hydrolyzable AMP analog
Product Description
AMP PNP is a non-hydrolyzable AMP analog. Kir6 (KATP) channel blocker. Inhibits fast axonal transport and stabilizes the interaction of membranous organelles with microtubules.Product Specifications
Molecular Weight
529.93
Formula
C10H13Li4N6O12P3
Storage
Store at -20°C
Purity
≥90% (HPLC)
Chemical Name
Adenosine-5'-[(β,γ)-imido]triphosphate tetralithium salt
CAS Number
72957-42-7
PubChem ID
44134521
InChI Key
FDBDJIGGLGUOPP-UHFFFAOYSA-J
SMILES
NC1=C2C(N([C@@H]3O[C@H](COP(OP(NP([O-])([O-])=O)([O-])=O)([O-])=O)[C@@H](O)[C@H]3O)C=N2)=NC=N1.[Li+].[Li+].[Li+].[Li+]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 26.5 | 50 |
Preparing Stock Solutions
for AMP PNP
The following data is based on the product molecular weight 529.93
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.77 mL | 18.87 mL | 37.74 mL |
| 2.5 mM | 0.75 mL | 3.77 mL | 7.55 mL |
| 5 mM | 0.38 mL | 1.89 mL | 3.77 mL |
| 25 mM | 0.08 mL | 0.38 mL | 0.75 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Yount Adenylyl imidodiphosphate, an adenosine triphosphate analog containing a P-N-P linkage. Biochemistry 1971 PMID: 4326768
- Hehl and Neumcke KATP channels of mouse skeletal muscle: mechanism of channel blockage by AMP-PNP. Eur.Biophys.J. 1994 PMID: 7805625
- Brady A novel brain ATPase with properties expected for the fast axonal transport motor. Nature 1985 PMID: 2412134
Product Specific Notices for AMP PNP
For research use only
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