Amisulpride
Tocris Bioscience, part of Bio-Techne | Catalog # 2132
Selective D2 and D3 antagonist; atypical antipsychotic
Discontinued Product
2132 has been discontinued.
View all Non-selective Dopamine Receptor Antagonists products.
Key Product Details
Description
Selective D2 and D3 antagonist; atypical antipsychotic
Alternative Names
DAN 2163
Product Description
Amisulpride is a potent, selective dopamine D2 and D3 receptor antagonist. Ki values are 2.8 and 3.2 nM respectively for human D2 and D3 and > 1000 nM for human D1, D4 and D5 receptors. Shows selectivity for presynaptic dopamine autoreceptors at low doses and blocks postsynaptic D2/D3 receptors at higher doses. Preferentially interacts with limbic D2-like receptors in vivo. Atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects and a profile distinct from that of haloperidol and remoxipride.Product Specifications
Molecular Weight
369.48
Formula
C17H27N3O4S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-benzamide
CAS Number
71675-85-9
PubChem ID
2159
InChI Key
NTJOBXMMWNYJFB-UHFFFAOYSA-N
SMILES
CCN1CCCC1CNC(=O)C1=C(OC)C=C(N)C(=C1)S(=O)(=O)CC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 9.24 | 25 with gentle warming | |
| DMSO | 18.47 | 50 |
Preparing Stock Solutions
for Amisulpride
The following data is based on the product molecular weight 369.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.41 mL | 27.07 mL | 54.13 mL |
| 2.5 mM | 1.08 mL | 5.41 mL | 10.83 mL |
| 5 mM | 0.54 mL | 2.71 mL | 5.41 mL |
| 25 mM | 0.11 mL | 0.54 mL | 1.08 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Schoemaker Neurochemical characteristics of amisulpride, an atypical DA D2/D3 receptor antagonist with both presynaptic and limbic selectivity. J.Pharmacol.Exp.Ther. 1997 PMID: 8996185
- Moller Amisulpride: limbic specificity and the mechanism of antipsychotic atypicality. Prog.Neuro-Psychopharm.Biol.Psychiat.
- Perrault Psychopharmacological profile of amisulpride: an antipsychotic drug with presynaptic D2/D3 DA receptor antagonist activity and limbic selectivity. J.Pharmacol.Exp.Ther. 1997 PMID: 8996184
Product Specific Notices for Amisulpride
For research use only
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