AMG 900

Product Description

AMG 900 is a potent pan-Aurora kinase inhibitor (IC₅₀ values are 1 nM, 4 nM, and 5 nM for Aurora C, B, and A, respectively). It is more than 10-fold selective for Aurora kinases over JNK2, Tie2, p38α, Met, and TYK2. AMG 900 inhibits autophosphorylation of Aurora A and B, as well as the phosphorylation of histone H3 on Ser in HeLa cells. AMG 900 inhibits proliferation of 26 tumor cell lines (EC₅₀ ranges from 0.7 nM - 5.3 nM), including Paclitaxel (Cat. No. 1097)-resistant tumor cell lines. In an HCT116 tumor xenograft model, AMG 900 inhibits phosphorylation of histone H3 and tumor growth. It is orally bioavailable.

Solubility

Preparing Stock Solutions for AMG 900

The following data is based on the product molecular weight 503.58

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.86 mL	99.29 mL	198.58 mL
0.5 mM	3.97 mL	19.86 mL	39.72 mL
1 mM	1.99 mL	9.93 mL	19.86 mL
5 mM	0.40 mL	1.99 mL	3.97 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Payton Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines. Cancer Res. 2010 PMID: 20935223