AMD 3465 hexahydrobromide

Name: AMD 3465 hexahydrobromide
Brand: Tocris Bioscience
SKU: 4179
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4179

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Citations (3)

COA / SDS

Potent and selective CXCR4 antagonist

Key Product Details

Description:	Potent and selective CXCR4 antagonist
Chemical Name:	N-[[4-(1,4,8,11-Tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-pyridinemethanamine hexahydrobromide
Purity:	≥97% (HPLC)
Molecular Weight:	896.07

View Full Technical Details for AMD 3465 hexahydrobromide

Technical Data
Citations / Reviews (1)

Biological Activity for AMD 3465 hexahydrobromide

AMD 3465 hexahydrobromide is a potent, selective CXCR4 antagonist; exhibits 8-fold higher affinity than AMD 3100 (Cat.No. 3299). Inhibits SDF-1α-ligand binding (K_i = 41.7 nM). Potently inhibits HIV cell entry in vitro; causes leukocytosis and mobilizes haematopoietic stem cells in vivo.

Compound Libraries for AMD 3465 hexahydrobromide

AMD 3465 hexahydrobromide is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for AMD 3465 hexahydrobromide

M. Wt	896.07
Formula	C₂₄H₃₈N₆.6HBr
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	185991-07-5
PubChem ID	9897616
InChi Key	ARHBIBDGWDRBJH-UHFFFAOYSA-N
Smiles	C1(CN3CCCNCCNCCCNCC3)=CC=C(CNCC2=NC=CC=C2)C=C1.Br.Br.Br.Br.Br.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AMD 3465 hexahydrobromide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	44.8	50
	DMSO	22.4	25

Preparing Stock Solutions for AMD 3465 hexahydrobromide

The following data is based on the product molecular weight 896.07.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	2.23 mL	11.16 mL	22.32 mL
2.5 mM	0.45 mL	2.23 mL	4.46 mL
5 mM	0.22 mL	1.12 mL	2.23 mL
25 mM	0.04 mL	0.22 mL	0.45 mL

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Reconstitution Calculator

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References for AMD 3465 hexahydrobromide

References are publications that support the biological activity of the product.

Bodart Pharmacology of AMD3465: A small molecule antagonist of the chemokine receptor CXCR4. Biochem.Pharmacol. 2009 PMID: 19540208
Rosenkilde Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists of the CXCR4 chemokine receptor. J.Biol.Chem. 2007 PMID: 17599916