AMBMP hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 6043
Wnt canonical signaling activator; also tubulin polymerization inhibitor
Key Product Details
Description
Wnt canonical signaling activator; also tubulin polymerization inhibitor
Alternative Names
BML 284,CID 11210285
Product Description
AMBMP hydrochloride is a Wnt canonical signaling activator. Also inhibits tubulin polymerization. Suppresses TLR2/4/5-induced inflammatory response in human monocytes. Inhibits cell proliferation and induces cell cycle arrest in MDA-MB-231 breast cancer cells. Also decreases embryo to blastocyst development.Product Specifications
Molecular Weight
386.84
Formula
C19H18N4O3.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N4-(1,3-Benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-2,4-pyrimidinediamine hydrochloride
CAS Number
2095432-75-8
PubChem ID
122705993
InChI Key
XZOFNDFDGVAIEH-UHFFFAOYSA-N
SMILES
COC1=CC=CC(C2=NC(N)=NC(NCC3=CC=C4OCOC4=C3)=C2)=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.68 | 100 |
Preparing Stock Solutions
for AMBMP hydrochloride
The following data is based on the product molecular weight 386.84
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.59 mL | 12.93 mL | 25.85 mL |
| 5 mM | 0.52 mL | 2.59 mL | 5.17 mL |
| 10 mM | 0.26 mL | 1.29 mL | 2.59 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Denicol Canonical WNT signaling regulates development of bovine embryos to the blastocyst stage. Sci.Rep. 2013 PMID: 23405280
- Wang 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine is an anti-inflammatory TLR-2, -4 and -5 response mediator in human monocytes. Inflamm.Res. 2016 PMID: 26613980
- Fukuda Tubulin is a molecular target of the Wnt-activating chemical probe. BMC Biochem. 2016 PMID: 27207629
- Liu A small-molecule agonist of the Wnt signaling pathway. Angew.Chem.Int.Ed.Engl. 2005 PMID: 15724259
Product Specific Notices for AMBMP hydrochloride
For research use only
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