AM 80
Tocris Bioscience, part of Bio-Techne | Catalog # 3507
RARα agonist; anticancer agent
Key Product Details
Description
RARα agonist; anticancer agent
Alternative Names
Tamibarotene
Product Description
AM 80 is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively) and displays anticancer activity against acute promyelocytic leukemia in vivo. AM 80 is a cell cycle activator in hiPSC-derived cardiomyocytes, and pretreatment with AM 80 promotes engraftment of cardiomyocytes in mice with heart damage.Product Specifications
Molecular Weight
351.44
Formula
C22H25NO3
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]benzoic acid
CAS Number
94497-51-5
PubChem ID
108143
InChI Key
MUTNCGKQJGXKEM-UHFFFAOYSA-N
SMILES
O=C(C3=CC=C(C(O)=O)C=C3)NC(C=C2)=CC1=C2C(C)(C)CCC(C)1C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.57 | 50 | |
| Ethanol | 17.57 | 50 |
Preparing Stock Solutions
for AM 80
The following data is based on the product molecular weight 351.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.69 mL | 28.45 mL | 56.91 mL |
| 2.5 mM | 1.14 mL | 5.69 mL | 11.38 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.69 mL |
| 25 mM | 0.11 mL | 0.57 mL | 1.14 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kasamoto Am80, a retinoic acid receptor agonist, activates the cardiomyocyte cell cycle and enhances engraftment in the heart. Stem Cell Reports 2023 PMID: 37451261
- Jimi RARα is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells. Int.J.Oncol. 2007 PMID: 17611697
- Takenaga The effects of Am-80, a synthetic retinoid, on spinal cord injury-induced motor dysfunction in rats. Biol.Pharm.Bull. 2009 PMID: 19182380
- Kagechika Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity. J.Med.Chem. 1988 PMID: 3184125
Product Specific Notices for AM 80
For research use only
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