AM 6545
Tocris Bioscience, part of Bio-Techne | Catalog # 5443
High affinity and selective CB1 antagonist
Key Product Details
Description
High affinity and selective CB1 antagonist
Product Description
AM 6545 is a high affinity and selective CB1 antagonist (Ki = 3.3 nM). Exhibits >100-fold selectivity for CB1 over CB2 receptors. Improves glucose homeostasis, reverses hepatic steatosis and reduces body weight in diet-induced obese mice. Orally available and non-brain penetrant.Product Specifications
Molecular Weight
556.46
Formula
C26H23Cl2N5O3S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
5-[4-(4-Cyano-1-butyn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxido-4-thiomorpholinyl)-4-methyl-1H-pyrazole-3-carboxamide
CAS Number
1245626-05-4
PubChem ID
46912919
InChI Key
XBHQLFVDGLPBCK-UHFFFAOYSA-N
SMILES
O=C(NN3CCS(CC3)(=O)=O)C1=NN(C2=CC=C(Cl)C=C2Cl)C(C4=CC=C(C#CCCC#N)C=C4)=C1C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 11.13 | 20 |
Preparing Stock Solutions
for AM 6545
The following data is based on the product molecular weight 556.46
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 8.99 mL | 44.93 mL | 89.85 mL |
| 1 mM | 1.80 mL | 8.99 mL | 17.97 mL |
| 2 mM | 0.90 mL | 4.49 mL | 8.99 mL |
| 10 mM | 0.18 mL | 0.90 mL | 1.80 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Bowles A peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated metabolic syndrome. Proc.Natl.Acad.Sci.U.S.A. 2015 PMID: 25535367
- Tam Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity. J.Clin.Invest. 2010 PMID: 20664173
Product Specific Notices for AM 6545
For research use only
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