AM 0902

Name: AM 0902
Brand: Tocris Bioscience
SKU: 5914

Tocris Bioscience, part of Bio-Techne | Catalog # 5914

Citations (10)

COA / SDS

Potent and selective TRPA1 antagonist

Key Product Details

Description:	Potent and selective TRPA1 antagonist
Chemical Name:	1-[[3-[2-(4-Chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl]methyl]-1,7-dihydro-7-methyl-6H-purin-6-one
Purity:	≥98% (HPLC)
Molecular Weight:	370.79

View Full Technical Details for AM 0902

Technical Data
Citations

Biological Activity for AM 0902

AM 0902 is a potent and selective TRPA1 antagonist (IC₅₀ = 0.02 μM for human TRPA1). Exhibits no siginificant activity against human TRPV1 or TRPV4, and rat TRPV1, TRPV3 or TRPM8. Exhibits efficacy in a rat pain model. Orally bioavailable.

Compound Libraries for AM 0902

AM 0902 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AM 0902

M. Wt	370.79
Formula	C₁₇H₁₅ClN₆O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1883711-97-4
PubChem ID	73297271
InChi Key	AWJBWNUUODWOKQ-UHFFFAOYSA-N
Smiles	CN1C=NC2=C1C(N(C=N2)CC3=NC(CCC4=CC=C(C=C4)Cl)=NO3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AM 0902

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	37.08	100

Preparing Stock Solutions for AM 0902

The following data is based on the product molecular weight 370.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.70 mL	13.48 mL	26.97 mL
5 mM	0.54 mL	2.70 mL	5.39 mL
10 mM	0.27 mL	1.35 mL	2.70 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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References for AM 0902

References are publications that support the biological activity of the product.

Schenkel Optimization of a novel quinazolinone-based series of transient receptor potential A1 (TRPA1) antagonists demonstrating potent in vivo activity. J.Med.Chem. 2016 PMID: 26942860