AIDA
Tocris Bioscience, part of Bio-Techne | Catalog # 0904
Potent and selective group I mGlu antagonist
Key Product Details
Description
Potent and selective group I mGlu antagonist
Alternative Names
UPF 523
Product Description
AIDA is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a), having no effect on group II (mGlu2) or group III (mGlu4) receptors expressed individually in baby hamster kidney cells. Has no effect on ionotropic glutamate receptors. Centrally active following systemic administration in vivo.Product Specifications
Molecular Weight
221.21
Formula
C11H11NO4
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(RS)-1-Aminoindan-1,5-dicarboxylic acid
CAS Number
168560-79-0
PubChem ID
2071
InChI Key
LSTPKMWNRWCNLS-UHFFFAOYSA-N
SMILES
NC2(C(O)=O)C1=CC=C(C(O)=O)C=C1CC2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1.1eq. NaOH | 22.12 | 100 |
Preparing Stock Solutions
for AIDA
The following data is based on the product molecular weight 221.21
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.52 mL | 22.60 mL | 45.21 mL |
| 5 mM | 0.90 mL | 4.52 mL | 9.04 mL |
| 10 mM | 0.45 mL | 2.26 mL | 4.52 mL |
| 50 mM | 0.09 mL | 0.45 mL | 0.90 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Nielsen Class I mGlu receptor antagonist 1-aminoindan-1,5-dicarboxylic acid blocks contextual but not cue conditioning in rats. Eur.J.Pharmacol. 1997 PMID: 9196260
- Pellicciari 1-Aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors. J.Med.Chem. 1995 PMID: 7562903
- Moroni Pharmacological characterization of 1-aminoindan-1,5-dicarboxylic acid, a potent mGluR1 antagonist. J.Pharmacol.Exp.Ther. 1997 PMID: 9152378
Product Specific Notices for AIDA
For research use only
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