AH 7614
Tocris Bioscience, part of Bio-Techne | Catalog # 5256
Selective FFA4 (GPR120) antagonist
Key Product Details
Description
Selective FFA4 (GPR120) antagonist
Product Description
AH 7614 is a selective free fatty acid receptor 4 (FFA4/GPR120) antagonist (pIC50 values are 7.1 and <4.6 for human FFA4 and FFA1 receptors respectively). Inhibits linoleic acid and GSK 137647A-induced intracellular calcium accumulation in U2OS osteosarcoma cells expressing the FFA4 receptor.Licensing Information
Sold for research purposes under agreement from GlaxoSmithKlineProduct Specifications
Molecular Weight
351.42
Formula
C20H17NO3S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-Methyl-N-9H-xanthen-9-yl-benzenesulfonamide
CAS Number
6326-06-3
PubChem ID
233085
InChI Key
OZCQEUZTOAAWDK-UHFFFAOYSA-N
SMILES
CC(C=C4)=CC=C4S(NC2C3=C(C=CC=C3)OC1=CC=CC=C12)(=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.14 | 100 |
Preparing Stock Solutions
for AH 7614
The following data is based on the product molecular weight 351.42
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.85 mL | 14.23 mL | 28.46 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.69 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.85 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sparks Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorg.Med.Chem.Lett. 2014 PMID: 24881566
Product Specific Notices for AH 7614
For research use only
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