AGN 192403 hydrochloride

Product Description

AGN 192403 hydrochloride is an i₁ imidazoline binding site selective ligand with a potency at I₁ comparable to moxonidine, but devoid of affinity for adrenoceptors and the I₂ binding site. Causes none of the physiological responses associated with the I₁ binding site in animal models. Also binds TMED9 cargo receptor. Releases MUC1-fs from TMED9 containing vesicles in kidney cells bearing MUC1 gene mutation

Solubility

Preparing Stock Solutions for AGN 192403 hydrochloride

The following data is based on the product molecular weight 189.73

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.27 mL	26.35 mL	52.71 mL
5 mM	1.05 mL	5.27 mL	10.54 mL
10 mM	0.53 mL	2.64 mL	5.27 mL
50 mM	0.11 mL	0.53 mL	1.05 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Dvela-Levitt Small molecule targets TMED9 and promotes lysosomal degradation to reverse proteinopathy. Cell 2019 PMID: 31348885
• Munk Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline₁ receptor specific agent. J.Med.Chem. 1996 PMID: 8632424
• Raasch Agmatine, an endogenous ligand at imidazoline binding sites, does not antagonize the clonidine-mediated blood pressure reaction. Br.J.Pharmacol. 2002 PMID: 11834614
• Mukaddam-Daher Receptors involved in moxonidine-stimulated strial natriuretic peptide released from isolated normotensive rat hearts. Eur.J.Pharmacol. 2006 PMID: 16774751