AF-DX 116
Tocris Bioscience, part of Bio-Techne | Catalog # 1105
Selective M2 antagonist
Key Product Details
Description
Selective M2 antagonist
Alternative Names
Otenzepad
Product Description
AF-DX 116 is a selective M2 muscarinic receptor antagonist. Ki values are 64, 417, 786, 211 and 5130 nM for human recombinant M2, M1, M3, M4 and M5 muscarinic receptors, respectively.Licensing Information
Sold with the permission of Boehringer Ingelheim GmbHProduct Specifications
Molecular Weight
421.54
Formula
C24H31N5O2
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
11-[[2-[(Diethylamino)methyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
CAS Number
102394-31-0
PubChem ID
107867
InChI Key
UBRKDAVQCKZSPO-UHFFFAOYSA-N
SMILES
CCN(CC)CC1CCCCN1CC(=O)N1C2=C(C=CC=C2)C(=O)NC2=CC=CN=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.54 | 25 with gentle warming |
Preparing Stock Solutions
for AF-DX 116
The following data is based on the product molecular weight 421.54
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 9.49 mL | 47.45 mL | 94.89 mL |
| 1.25 mM | 1.90 mL | 9.49 mL | 18.98 mL |
| 2.5 mM | 0.95 mL | 4.74 mL | 9.49 mL |
| 12.5 mM | 0.19 mL | 0.95 mL | 1.90 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mansfield Muscarinic receptor subtypes in human bladder detrusor and mucosa, studied by radioligand binding and quantitative competitive RT-PCR: changes in ageing. Br.J.Pharmacol. 2005 PMID: 15723094
- Eglen Muscarinic receptor subtypes and smooth muscle function. Pharmacol.Rev. 1996 PMID: 8981565
- Hammer Binding profile of a novel cardioselective muscarinic receptor antagonist, AF-DX 116, to membranes of peripheral tissues and brain in the rat. Life Sci. 1986 PMID: 3754610
- Billard Identification of the primary muscarinic autoreceptor subtype in rat striatum as M2 through a correlation of in vivo microdialysis and in vitro receptor binding data. J.Pharmacol.Exp.Ther. 1995 PMID: 7714776
Product Specific Notices for AF-DX 116
For research use only
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