ADX 10059 hydrochloride

Name: ADX 10059 hydrochloride
Brand: Tocris Bioscience
SKU: 4416

Tocris Bioscience, part of Bio-Techne | Catalog # 4416

Citations (2)

COA / SDS

Negative allosteric modulator of mGlu5 receptors

Key Product Details

Description:	Negative allosteric modulator of mGlu₅ receptors
Alternative Names:	Raseglurant
Chemical Name:	2-[(3-Fluorophenyl)ethynyl]-4,6-dimethyl-3-pyridinamine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	276.74

View Full Technical Details for ADX 10059 hydrochloride

Technical Data
Citations

Biological Activity for ADX 10059 hydrochloride

ADX 10059 hydrochloride is reported to be a negative allosteric modulator at the mGlu₅ receptor. Analog of MPEP (Cat. No. 1212).

Compound Libraries for ADX 10059 hydrochloride

ADX 10059 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ADX 10059 hydrochloride

M. Wt	276.74
Formula	C₁₅H₁₃FN₂.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	757949-98-7
PubChem ID	18454771
InChi Key	BDXXMGYKLQZXOU-UHFFFAOYSA-N
Smiles	CC1=CC(C)=NC(C#CC2=CC=CC(F)=C2)=C1N.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ADX 10059 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	6.92	25
	DMSO	27.67	100

Preparing Stock Solutions for ADX 10059 hydrochloride

The following data is based on the product molecular weight 276.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.61 mL	18.07 mL	36.14 mL
5 mM	0.72 mL	3.61 mL	7.23 mL
10 mM	0.36 mL	1.81 mL	3.61 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

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References for ADX 10059 hydrochloride

References are publications that support the biological activity of the product.

Keywood A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease. Gut. 2009 PMID: 19460767
Marin and Goadsby Glutamatergic fine tuning with ADX-10059: a novel therapeutic approach for migraine? Expert Opin.Invest.Drugs 2010 PMID: 20218930
Weiss 6-Aryl-3-pyrrolidinylpyridines as mGlu5 receptor negative allosteric modulators. Bioorg.Med.Chem.Lett. 2011 PMID: 21757343