AdipoRon hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5096
Orally active AdipoR1 and AdipoR2 agonist; antidiabetic
Key Product Details
Description
Orally active AdipoR1 and AdipoR2 agonist; antidiabetic
Product Description
AdipoRon hydrochloride is an agonist of adiponectin receptors AdipoR1 and AdipoR2 (Kd values are 1.8 and 3.1 μM respectively). Activates AMPK and PPARα signaling; ameliorates insulin resistance, dyslipidemia and glucose intolerance in db/db mice. Orally active antidiabetic agent.Product Specifications
Molecular Weight
464.98
Formula
C27H28N2O3.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
2-(4-Benzyoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide hydrochloride
CAS Number
1781835-20-8
PubChem ID
78243714
InChI Key
TZVJQEGKRLDTHQ-UHFFFAOYSA-N
SMILES
O=C(C2=CC=C(OCC(NC3CCN(CC4=CC=CC=C4)CC3)=O)C=C2)C1=CC=CC=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.5 | 100 | |
| Ethanol | 4.65 | 10 |
Preparing Stock Solutions
for AdipoRon hydrochloride
The following data is based on the product molecular weight 464.98
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.15 mL | 10.75 mL | 21.51 mL |
| 5 mM | 0.43 mL | 2.15 mL | 4.30 mL |
| 10 mM | 0.22 mL | 1.08 mL | 2.15 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Okada-Iwabu A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature 2013 PMID: 24172895
Product Specific Notices for AdipoRon hydrochloride
For research use only
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