Acetyl-Calpastatin (184-210) (human)
Tocris Bioscience, part of Bio-Techne | Catalog # 2950
Selective calpain inhibitor
Discontinued Product
2950 has been discontinued.
View all Calpain Inhibitors products.
Product Description
Acetyl-Calpastatin (184-210) (human) is a selective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 μM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio.Product Specifications
Molecular Weight
3177.65
Formula
C142H230N36O44S
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
123714-50-1
PubChem ID
90488788
InChI Key
ZXJCOYBPXOBJMU-HSQGJUDPSA-N
SMILES
CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 5mg/ml in water |
Calculators
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Background References
References are publications that support the biological activity of the product.
- Yamazaki Specific increase in amyloid β-protein 42 secretion ratio by calpain inhibition. Biochem.
- Fiorino A new cell-permeable calpain inhibitor. J.Peptide Sci.
- Maki Inhibition of calapin by a synthetic oligopeptide corresponding to an exon of the human calpastatin gene. J.Biol.Chem. 1989 PMID: 2553724
Product Specific Notices for Acetyl-Calpastatin (184-210) (human)
For research use only
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