Ac-FLTD-CMK
Tocris Bioscience, part of Bio-Techne | Catalog # 7242
Potent and selective inhibitor of caspases 1, 5 and 4
Key Product Details
Description
Potent and selective inhibitor of caspases 1, 5 and 4
Product Description
Ac-FLTD-CMK is a potent and selective inhibitor of caspases 1, 5 and 4 (IC50 values = 46.7 nM, 0.33 μM, 1.49 μM, respectively), and inhibits murine caspase-11 at 10 μM. Ac-FLTD-CMK inhibits cleavage of gasdermin D by caspases, suppresses pyroptosis and reduces IL-1β release in macrophages.Product Specifications
Molecular Weight
569.05
Formula
C26H37ClN4O8
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
2376255-48-8
PubChem ID
155906572
InChI Key
UCWNTWGHVCSMJP-WPUDHWPRSA-N
SMILES
O=C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(CCl)=O)=O)=O)[C@H](CC1=CC=CC=C1)NC(C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 1mg/ml in DMSO |
Calculators
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Background References
References are publications that support the biological activity of the product.
- Yang Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Proc.Natl.Acad.Sci.U.S.A. 2018 PMID: 29891674
Product Specific Notices for Ac-FLTD-CMK
For research use only
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