AC 265347

Tocris Bioscience, part of Bio-Techne | Catalog # 6165

Biased allosteric modulator of calcium-sensing receptor (CaSR)
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Key Product Details

Description

Biased allosteric modulator of calcium-sensing receptor (CaSR)

View all Calcium-Sensing Receptor Modulators »

Product Description

AC 265347 is a CaSR biased allosteric modulator (pEC50 = 7.8-8.1). Calcimimetic. Displays ability to bias signalling towards the accumulation of pERK1/2 and IP1. Reduces parathyroid hormone (PTH) levels in rat serum without inducing the release of calcitonin. Exhibits no significant activation of human GABAB or type I PTH receptors. Orally active.

Product Specifications

Molecular Weight

283.39

Formula

C17H17NOS

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

α-(2,4-Dimethylphenyl)-α-methyl-2-benzothiazolemethanol

CAS Number

1253901-26-6

PubChem ID

52943938

InChI Key

IGSZVEPQZANNAB-UHFFFAOYSA-N

SMILES

CC1=CC(C)=C(C(O)(C2=NC3=CC=CC=C3S2)C)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.34 100
Ethanol 28.34 100

Preparing Stock Solutions for AC 265347

The following data is based on the product molecular weight 283.39

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.53 mL 17.64 mL 35.29 mL
5 mM 0.71 mL 3.53 mL 7.06 mL
10 mM 0.35 mL 1.76 mL 3.53 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for AC 265347

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AC 265347

For research use only

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