AC 1903
Tocris Bioscience, part of Bio-Techne | Catalog # 6766
Selective TRPC5 inhibitor
Product Description
AC 1903 is a selective TRPC5 blocker (IC50 = 4.0 - 13.6 μM). Also displays weak inhibition at TRPC4 (IC50 >100 μM) but not TRPC6. Exhibits no effect against a standard panel of profiling kinases. Blocks TRPC5 channel activity in glomeruli of proteinuric rats. Suppresses severe proteinuria and prevents podocyte loss in a transgenic rat model of focal segmental glomerulosclerosis (FSGS).Product Specifications
Molecular Weight
303.36
Formula
C19H17N3O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(2-Furanylmethyl)-1-(phenylmethyl)-1H-benzimidazol-2-amine
CAS Number
831234-13-0
PubChem ID
667146
InChI Key
OECUWHDVQIITIS-UHFFFAOYSA-N
SMILES
C1(NCC2=CC=CO2)=NC3=CC=CC=C3N1CC4=CC=CC=C4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 15.17 | 50 |
Preparing Stock Solutions
for AC 1903
The following data is based on the product molecular weight 303.36
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6.59 mL | 32.96 mL | 65.93 mL |
| 2.5 mM | 1.32 mL | 6.59 mL | 13.19 mL |
| 5 mM | 0.66 mL | 3.30 mL | 6.59 mL |
| 25 mM | 0.13 mL | 0.66 mL | 1.32 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sharma Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903. Bioorg.Med.Chem.Lett. 2019 PMID: 30538066
- Zhou A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models. Science 2017 PMID: 29217578
- Minard Remarkable progress with small-molecule modulation of TRPC1/4/5 channels: implications for understanding the channels in health and disease. Cells 2018 PMID: 29865154
- Chung TRP'ing up chronic kidney disease. Science 2017 PMID: 29217557
Product Specific Notices for AC 1903
For research use only
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