ABX 464

Name: ABX 464
Brand: Tocris Bioscience
SKU: 6460

Tocris Bioscience, part of Bio-Techne | Catalog # 6460

COA / SDS

HIV RNA splicing modulator

Key Product Details

Description:	HIV RNA splicing modulator
Chemical Name:	8-Chloro-N-[4-(trifluoromethoxy)phenyl]-2-quinolinamine
Purity:	≥98% (HPLC)
Molecular Weight:	338.71

View Full Technical Details for ABX 464

Technical Data
Citations

Biological Activity for ABX 464

ABX 464 is an HIV RNA splicing modulator; it selectively enhances the splicing of HIV RNA in infected human PBMCs and inhibits viral replication, with no global effect on cellular splicing. ABX 464 inhibits replication of HIV strains harboring mutations associated with drug-resistance. ABX 464 binds the cap binding complex (CBC) and upregulates miR-124 expression in vitro and decreases expression of miR-124 target genes, MCP-1, CXCL-1, SERPIN-E1 in macrophages. It also decreases the number of Th17 cells, as well as IL-6 soluble receptor in CD4+ T cells. In HIV infected humanized mice, treatment with ABX 464 reduces viral load. Anti-inflammatory.

Technical Data for ABX 464

M. Wt	338.71
Formula	C₁₆H₁₀ClF₃N₂O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1258453-75-6
PubChem ID	49846599
InChi Key	OZOGDCZJYVSUBR-UHFFFAOYSA-N
Smiles	FC(F)(F)OC1=CC=C(C=C1)NC=2N=C3C(Cl)=CC=CC3=CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ABX 464

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.87	100
	ethanol	33.87	100

Preparing Stock Solutions for ABX 464

The following data is based on the product molecular weight 338.71.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.95 mL	14.76 mL	29.52 mL
5 mM	0.59 mL	2.95 mL	5.90 mL
10 mM	0.30 mL	1.48 mL	2.95 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

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References for ABX 464

References are publications that support the biological activity of the product.

Vautrin Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediated by modulation of RNA splicing. Sci.Rep. 2018 PMID: 30692590
Campos Long lasting control of viral rebound with a new drug ABX464 targeting Rev-mediated viral RNA biogenesis. Retrovirology 2015 PMID: 25889234