ABT 724 trihydrochloride

Name: ABT 724 trihydrochloride
Brand: Tocris Bioscience
SKU: 2214

Tocris Bioscience, part of Bio-Techne | Catalog # 2214

COA / SDS

Potent and selective D4 partial agonist; proerectile

Discontinued Product

2214 has been discontinued. View all Dopamine D4 Receptor Agonists products.

Key Product Details

Description:	Potent and selective D₄ partial agonist; proerectile
Chemical Name:	2-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole trihydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	402.75

View Full Technical Details for ABT 724 trihydrochloride

Technical Data
Citations

Biological Activity for ABT 724 trihydrochloride

ABT 724 trihydrochloride is an ABT 724 is a potent dopamine D₄ receptor partial agonist (EC₅₀ = 12.4 nM; 61% efficacy vs. dopamine), which displays no agonist activity at D₂ receptors (EC₅₀ > 10 μM). ABT 724 is selective in rats in vivo and produces penile erection following i.c.v. administration, and increases intracavernosal pressure and potentiates the proerectile effects of sildenafil following s.c. administration. This compound displays minimal side effects.

External Portal information

The Chemical Probes webpages of the Structural Genomics Consortium are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of ABT 724 is reviewed on the chemical probes website.

Technical Data for ABT 724 trihydrochloride

M. Wt	402.75
Formula	C₁₇H₁₉N₅.3HCl
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	587870-77-7
PubChem ID	16759165
InChi Key	AZFUVPBLKQGSRI-UHFFFAOYSA-N
Smiles	Cl.Cl.Cl.C(N1CCN(CC1)C1=NC=CC=C1)C1=NC2=CC=CC=C2N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for ABT 724 trihydrochloride

References are publications that support the biological activity of the product.

Cowart Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a DArgic agent with a novel mode of action for the potential treatment of erectile dysfunction. J.Med.Chem. 2004 PMID: 15239663
Brioni Activation of DA D₄ receptors by ABT-724 induces penile erection in rats. Proc.Natl.Acad.Sci.USA
Stewart DA D₄ ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning. J.Med.Chem. 2004 PMID: 15084133