ABT 089 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5079
High affinity and selective α4β2 nAChR partial agonist
Key Product Details
Description
High affinity and selective α4β2 nAChR partial agonist
Product Description
ABT 089 dihydrochloride is a high affinity and selective α4β2 partial agonist (Ki = 16 nM). Exhibits >1000-fold and >10,000-fold selectivity for α4β2 over α1β1γ1 and α7 receptors respectively. Neuroprotective against glutamate-induced toxicity in rat cortical neurons in vitro. Enhances cognitive performance in vivo. Orally bioavailable and brain penetrant.Product Specifications
Molecular Weight
265.18
Formula
C11H16N2O.2HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
2-Methyl-3-[(2S)-pyrrolidinylmethoxy]pyridine dihydrochloride
CAS Number
161416-61-1
PubChem ID
23729426
InChI Key
UGVSESCRKJTJAK-XRIOVQLTSA-N
SMILES
CC1=NC=CC=C1OC[C@H]2NCCC2.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 26.52 | 100 | |
| DMSO | 5.3 | 20 |
Preparing Stock Solutions
for ABT 089 dihydrochloride
The following data is based on the product molecular weight 265.18
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.77 mL | 18.86 mL | 37.71 mL |
| 5 mM | 0.75 mL | 3.77 mL | 7.54 mL |
| 10 mM | 0.38 mL | 1.89 mL | 3.77 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.75 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sullivan ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties. J.Pharmacol.Exp.Ther. 1997 PMID: 9336329
- Decker ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A novel cholinergic channel modulator with effects on cognitive performance in rats and monkeys. J.Pharmacol.Exp.Ther. 1997 PMID: 9336330
- Rueter ABT-089: pharmacological properties of a neuronal nicotinic acetylcholine receptor agonist for the potential treatment of cognitive disorders. CNS Drug Rev. 2004 PMID: 15179445
Product Specific Notices for ABT 089 dihydrochloride
For research use only
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