ABT 089 dihydrochloride

Name: ABT 089 dihydrochloride
Brand: Tocris Bioscience
SKU: 5079

Tocris Bioscience, part of Bio-Techne | Catalog # 5079

COA / SDS

High affinity and selective α4β2 nAChR partial agonist

Key Product Details

Description:	High affinity and selective α4β2 nAChR partial agonist
Chemical Name:	2-Methyl-3-[(2S)-pyrrolidinylmethoxy]pyridine dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	265.18

View Full Technical Details for ABT 089 dihydrochloride

Technical Data
Citations

Biological Activity for ABT 089 dihydrochloride

ABT 089 dihydrochloride is a high affinity and selective α4β2 partial agonist (K_i = 16 nM). Exhibits >1000-fold and >10,000-fold selectivity for α4β2 over α1β1γ1 and α7 receptors respectively. Neuroprotective against glutamate-induced toxicity in rat cortical neurons in vitro. Enhances cognitive performance in vivo. Orally bioavailable and brain penetrant.

Technical Data for ABT 089 dihydrochloride

M. Wt	265.18
Formula	C₁₁H₁₆N₂O.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	161416-61-1
PubChem ID	23729426
InChi Key	UGVSESCRKJTJAK-XRIOVQLTSA-N
Smiles	CC1=NC=CC=C1OC[C@H]2NCCC2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ABT 089 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	26.52	100
	DMSO	5.3	20

Preparing Stock Solutions for ABT 089 dihydrochloride

The following data is based on the product molecular weight 265.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.77 mL	18.86 mL	37.71 mL
5 mM	0.75 mL	3.77 mL	7.54 mL
10 mM	0.38 mL	1.89 mL	3.77 mL
50 mM	0.08 mL	0.38 mL	0.75 mL

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References for ABT 089 dihydrochloride

References are publications that support the biological activity of the product.

Sullivan ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties. J.Pharmacol.Exp.Ther. 1997 PMID: 9336329
Decker ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A novel cholinergic channel modulator with effects on cognitive performance in rats and monkeys. J.Pharmacol.Exp.Ther. 1997 PMID: 9336330
Rueter ABT-089: pharmacological properties of a neuronal nicotinic acetylcholine receptor agonist for the potential treatment of cognitive disorders. CNS Drug Rev. 2004 PMID: 15179445