A 867744

Name: A 867744
Brand: Tocris Bioscience
SKU: 4571

Tocris Bioscience, part of Bio-Techne | Catalog # 4571

Citations (2)

COA / SDS

Positive allosteric modulator of α7 nAChRs

Key Product Details

Description:	Positive allosteric modulator of α7 nAChRs
Chemical Name:	4-[5-(4-Chlorophenyl)-2-methyl-3-(1-oxopropyl)-1H-pyrrol-1-yl]benzenesulfonamide
Purity:	≥97% (HPLC)
Molecular Weight:	402.89

View Full Technical Details for A 867744

Technical Data
Citations

Biological Activity for A 867744

A 867744 is a positive allosteric modulator of α7 nAChRs (IC₅₀ values are 0.98 and 1.12 μM for human and rat α7 receptor ACh-evoked currents respectively, in X. laevis oocytes). Displays no activity at 5-HT_3A, α3β4 or α4β2 nAChRs. Brain penetrant.

Technical Data for A 867744

M. Wt	402.89
Formula	C₂₀H₁₉ClN₂O₃S
Storage	Store at +4°C
Purity	≥97% (HPLC)
CAS Number	1000279-69-5
PubChem ID	23642319
InChi Key	ABACVOXFUHDKNZ-UHFFFAOYSA-N
Smiles	O=C(CC)C1=C(C)N(C3=CC=C(S(N)(=O)=O)C=C3)C(C2=CC=C(Cl)C=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 867744

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.29	100
	ethanol	4.03	10 with gentle warming

Preparing Stock Solutions for A 867744

The following data is based on the product molecular weight 402.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.48 mL	12.41 mL	24.82 mL
5 mM	0.50 mL	2.48 mL	4.96 mL
10 mM	0.25 mL	1.24 mL	2.48 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for A 867744

References are publications that support the biological activity of the product.

Faghih Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the α7 nicotinic acetylcholine receptor. J.Med.Chem. 2009 PMID: 19419141
Malysz In vitro pharmacological characterization of a novel allosteric modulator of α 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting J.Pharmacol.Exp.Ther. 2009 PMID: 19389923