A 839977

Tocris Bioscience, part of Bio-Techne | Catalog # 4232

Potent P2X7 antagonist
Discontinued Product
4232 has been discontinued. View all P2X Receptor Antagonists products.

Key Product Details

Description

Potent P2X7 antagonist

View all P2X Receptor Antagonists »

Product Description

A 839977 is a potent P2X7 antagonist; blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors (IC50 values are 20, 42 and 150 nM respectively). Displays antinociceptive effects in rat and mice models of inflammatory pain. CNS penetrant.

Product Specifications

Molecular Weight

413.26

Formula

C19H14Cl2N6O

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1-(2,3-Dichlorophenyl)-N-[[2-(2-pyridinyloxy)phenyl]methyl]-1H-tetrazol-5-amine

CAS Number

870061-27-1

PubChem ID

53325875

InChI Key

GMVNBKZQJFRFAR-UHFFFAOYSA-N

SMILES

ClC(C(Cl)=CC=C4)=C4N1N=NN=C1NCC2=CC=CC=C2OC3=NC=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.33 100

Preparing Stock Solutions for A 839977

The following data is based on the product molecular weight 413.26

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.42 mL 12.10 mL 24.20 mL
5 mM 0.48 mL 2.42 mL 4.84 mL
10 mM 0.24 mL 1.21 mL 2.42 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for A 839977

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for A 839977

For research use only

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