A 804598
Tocris Bioscience, part of Bio-Techne | Catalog # 4473
Potent and selective P2X7 antagonist
Key Product Details
Description
Potent and selective P2X7 antagonist
Product Description
A 804598 is a potent, competitive P2X7 receptor antagonist (IC50 values are 8.9, 9.9 and 10.9 nM for mouse, rat and human P2X7 receptors respectively). Selective for P2X7 receptors (IC50 > 5-10 μM for a wide array of cell surface receptors and ion channels). Binds with high affinity (Ki app = 2.4 nM for rat P2X7 receptors).Product Specifications
Molecular Weight
315.37
Formula
C19H17N5
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-Cyano-N"-[(1S)-1-phenylethyl]-N'-5-quinolinyl-guanidine
CAS Number
1125758-85-1
PubChem ID
53325874
InChI Key
PQYCRDPLPKGSME-AWEZNQCLSA-N
SMILES
C[C@@H](C3=CC=CC=C3)NC(NC2=CC=CC1=NC=CC=C12)=NC#N
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.54 | 100 |
Preparing Stock Solutions
for A 804598
The following data is based on the product molecular weight 315.37
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.17 mL | 15.85 mL | 31.71 mL |
| 5 mM | 0.63 mL | 3.17 mL | 6.34 mL |
| 10 mM | 0.32 mL | 1.59 mL | 3.17 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.63 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Able Receptor localization, native tissue binding and ex vivo occupancy for centrally penetrant P2X7 antagonists in the rat. Br.J.Pharmacol. 2011 PMID: 20840537
- Donnelly-Roberts [3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors. Neuropharmacology 2009 PMID: 18602931
Product Specific Notices for A 804598
For research use only
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