A 582941

Name: A 582941
Brand: Tocris Bioscience
SKU: 4341

Tocris Bioscience, part of Bio-Techne | Catalog # 4341

COA / SDS

α7 nAChR partial agonist

Key Product Details

Description:	α7 nAChR partial agonist
Chemical Name:	Octahydro-2-methyl-5-(6-phenyl-3-pyridazinyl)-pyrrolo[3,4-c]pyrrole
Purity:	≥98% (HPLC)
Molecular Weight:	280.37

View Full Technical Details for A 582941

Technical Data
Citations

Biological Activity for A 582941

A 582941 is a selective α7 nAChR partial agonist; exhibits high affinity for both rat and human α7 receptors (K_i values are 10.8 and 16.7 nM respectively). Displays ~15-fold selectivity for α7 over 5-HT₃ receptors (K_i = 150 nM for 5-HT₃).

Technical Data for A 582941

M. Wt	280.37
Formula	C₁₇H₂₀N₄
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	848591-90-2
PubChem ID	44190553
InChi Key	GTMRUYCIJSNXGB-GASCZTMLSA-N
Smiles	[H][C@@]12[C@@](CN(C3=CC=C(C4=CC=CC=C4)N=N3)C2)([H])CN(C)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 582941

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	28.04	100
	1eq. HCl	14.02	50

Preparing Stock Solutions for A 582941

The following data is based on the product molecular weight 280.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.57 mL	17.83 mL	35.67 mL
5 mM	0.71 mL	3.57 mL	7.13 mL
10 mM	0.36 mL	1.78 mL	3.57 mL
50 mM	0.07 mL	0.36 mL	0.71 mL

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References for A 582941

References are publications that support the biological activity of the product.

Anderson [3H]A-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a novel high-affinity α7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain J.Pharmacol.Exp.Ther. 2008 PMID: 17959745