8MDP
Tocris Bioscience, part of Bio-Techne | Catalog # 4588
Potent equilibrative nucleoside transporter (ENT) inhibitor
Key Product Details
Description
Potent equilibrative nucleoside transporter (ENT) inhibitor
Product Description
8MDP is a potent equilibrative nucleoside transporter 1 (ENT1) inhibitor (IC50 = 0.43 nM). Inhibits hENT1 and hENT2 uptake of [H3]uridine in K562 cells and K15NTD cells respectively.Product Specifications
Molecular Weight
560.73
Formula
C28H48N8O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2,2',2'',2'''-[[4,8-Bis(hexahydro-1(2H)-azocinyl)pyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilo]tetrakisethanol
CAS Number
29491-75-6
PubChem ID
16756415
InChI Key
KXOCTHJHIGLQKJ-UHFFFAOYSA-N
SMILES
OCCN(CCO)C2=NC1=C(N3CCCCCCC3)N=C(N(CCO)CCO)N=C1C(N4CCCCCCC4)=N2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 11.21 | 20 |
Preparing Stock Solutions
for 8MDP
The following data is based on the product molecular weight 560.73
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 8.92 mL | 44.58 mL | 89.17 mL |
| 1 mM | 1.78 mL | 8.92 mL | 17.83 mL |
| 2 mM | 0.89 mL | 4.46 mL | 8.92 mL |
| 10 mM | 0.18 mL | 0.89 mL | 1.78 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lin Synthesis, flow cytometric evaluation, and identification of highly potent dipyrid. analogues as equilibrative nucleoside transporter 1 inhibitors. J.Med.Chem. 2007 PMID: 17636949
- Lin Design, synthesis, and evaluation of 2-diethanolamino-4,8-diheptamethyleneimino-2-(N-aminoethyl-N-ethanolamino)-6-(N,N-diethanolamino)pyrimido[5,4-d]pyrimidine-fluorescein conjugate (8MDP-fluor), as a novel equilibrativ Bioconjug.Chem. 2011 PMID: 21539390
Product Specific Notices for 8MDP
For research use only
Loading...
Loading...