8-Chloroadenosine

Tocris Bioscience, part of Bio-Techne | Catalog # 4436

Cytotoxic nucleoside analog; inhibits RNA synthesis
Discontinued Product
4436 has been discontinued. View all DNA, RNA and Protein Synthesis Inhibitors products.

Key Product Details

Description

Cytotoxic nucleoside analog; inhibits RNA synthesis

View all DNA, RNA and Protein Synthesis Inhibitors »

Product Description

8-Chloroadenosine is a nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226 and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells.

Product Specifications

Molecular Weight

301.69

Formula

C10H12ClN5O4

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

6-Amino-8-chloropurine riboside

CAS Number

34408-14-5

PubChem ID

90488943

InChI Key

MHDPPLULTMGBSI-LZGMGDPASA-N

SMILES

O[C@@H]1[C@@H](CO)OC(N3C2=NC=NC(N)=C2N=C3Cl)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 6.03 20 with gentle warming
DMSO 30.17 100

Preparing Stock Solutions for 8-Chloroadenosine

The following data is based on the product molecular weight 301.69

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.31 mL 16.57 mL 33.15 mL
5 mM 0.66 mL 3.31 mL 6.63 mL
10 mM 0.33 mL 1.66 mL 3.31 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

Calculators

Molarity Calculator

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for 8-Chloroadenosine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 8-Chloroadenosine

For research use only

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