8-Azaadenosine
Tocris Bioscience, part of Bio-Techne | Catalog # 6868
ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor; inhibits leukemia stem cell self-renewal
Key Product Details
Description
ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor; inhibits leukemia stem cell self-renewal
Product Description
8-Azaadenosine is an ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor. Reduces A-to-I editing activity in a leukemia cell line, restores let-7 and inhibits leukemia stem cells self-renewal in vitro.Product Specifications
Molecular Weight
268.23
Formula
C9H12N6O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3-β-D-Ribofuranosyl-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine
CAS Number
10299-44-2
PubChem ID
96410
InChI Key
OAUKGFJQZRGECT-UUOKFMHZSA-N
SMILES
NC1=NC=NC2=C1N=NN2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.82 | 100 |
Preparing Stock Solutions
for 8-Azaadenosine
The following data is based on the product molecular weight 268.23
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.73 mL | 18.64 mL | 37.28 mL |
| 5 mM | 0.75 mL | 3.73 mL | 7.46 mL |
| 10 mM | 0.37 mL | 1.86 mL | 3.73 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.75 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zhang and Slack ADARs edit microRNAs to promote leukemic stem cell activity. Cell Stem Cell 2016 PMID: 27494666
- Zipeto ADAR1 activation drives leukemia stem cell self-renewal by impairing let-7 biogenesis. Cell Stem Cell 2016 PMID: 27292188
Product Specific Notices for 8-Azaadenosine
For research use only
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