7rh
Tocris Bioscience, part of Bio-Techne | Catalog # 5860
Potent and selective DDR1 inhibitor; orally bioavailable
Key Product Details
Description
Potent and selective DDR1 inhibitor; orally bioavailable
Product Description
7rh is a potent and selective DDR1 inhibitor (IC50 = 6.8 nM). Exhibits selectivity for DDR1 over DDR2, Bcr-Abl and c-Kit (IC50 values are 101.4 and 355 nM and > 10 μM, respectively) and a range of other kinases. Inhibits proliferation of cancer cell lines expressing high levels of DDR1 in vitro and suppresses cancer cell invasion, adhesion and tumorigenicity. Orally bioavailable.Product Specifications
Molecular Weight
546.59
Formula
C30H29F3N6O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-Ethyl-N-[3-[(4-methyl-1-piperazinyl)methyl]-5-(trifluoromethyl)phenyl]-3-(2-pyrazolo[1,5-a]pyrimidin-6-ylethynyl)benzamide
CAS Number
1429617-90-2
PubChem ID
71550931
InChI Key
DDLPXZXBWGJRGK-UHFFFAOYSA-N
SMILES
O=C(NC1=CC(CN2CCN(C)CC2)=CC(C(F)(F)F)=C1)C3=CC(C#CC(C=N4)=CN5C4=CC=N5)=C(CC)C=C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 54.66 | 100 |
Preparing Stock Solutions
for 7rh
The following data is based on the product molecular weight 546.59
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.83 mL | 9.15 mL | 18.30 mL |
| 5 mM | 0.37 mL | 1.83 mL | 3.66 mL |
| 10 mM | 0.18 mL | 0.91 mL | 1.83 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.37 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
Product Specific Notices for 7rh
For research use only
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