4-P-PDOT

Name: 4-P-PDOT
Brand: Tocris Bioscience
SKU: 1034

Tocris Bioscience, part of Bio-Techne | Catalog # 1034

Citations (49)

COA / SDS

MT2 antagonist

Key Product Details

Description:	MT₂ antagonist
Alternative Names:	AH 024
Chemical Name:	cis-4-Phenyl-2-propionamidotetralin
Purity:	≥98% (HPLC)
Molecular Weight:	279.38

View Full Technical Details for 4-P-PDOT

Technical Data
Citations

Biological Activity for 4-P-PDOT

4-P-PDOT is a melatonin receptor antagonist, >300-fold selective for the MT₂ (vs MT₁) subtype.

Compound Libraries for 4-P-PDOT

4-P-PDOT is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for 4-P-PDOT

M. Wt	279.38
Formula	C₁₉H₂₁NO
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	620170-78-7
PubChem ID	3976006
InChi Key	RCYLUNPFECYGDW-UHFFFAOYSA-N
Smiles	CCC(=O)NC1CC(C2=CC=CC=C2)C2=C(C1)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 4-P-PDOT

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	27.94	100
	ethanol	27.94	100

Preparing Stock Solutions for 4-P-PDOT

The following data is based on the product molecular weight 279.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.58 mL	17.90 mL	35.79 mL
5 mM	0.72 mL	3.58 mL	7.16 mL
10 mM	0.36 mL	1.79 mL	3.58 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

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Reconstitution Calculator

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References for 4-P-PDOT

References are publications that support the biological activity of the product.

Dubocovich Melatonin receptors: are there multiple subtypes? TiPS 1995 PMID: 7762083
Dubocovich Melatonin receptor antagonists that differentiate between the human Mel_1a and Mel_1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina M_L1 presynaptic heteroceptor. Naunyn Schmiedebergs Arch.Pharmacol. 1997 PMID: 9089668