4-Octyl itaconate
Tocris Bioscience, part of Bio-Techne | Catalog # 6662
Nrf2 activator; cell permeable
Product Description
4-Octyl itaconate activates Nrf2. Inhibits LPS-induced increases in IL-1β mRNA, HIF-1α and IL-10 in macrophages. Decreases cytokine production in response to LPS in mice and prolongs survival. Cell permeable.Product Specifications
Molecular Weight
242.31
Formula
C13H22O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-Methylenebutanedioic acid 4-octyl ester
CAS Number
3133-16-2
PubChem ID
14239884
InChI Key
KBASUIDPDITQHT-UHFFFAOYSA-N
SMILES
CCCCCCCCOC(CC(C(O)=O)=C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.23 | 100 |
Preparing Stock Solutions
for 4-Octyl itaconate
The following data is based on the product molecular weight 242.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.13 mL | 20.63 mL | 41.27 mL |
| 5 mM | 0.83 mL | 4.13 mL | 8.25 mL |
| 10 mM | 0.41 mL | 2.06 mL | 4.13 mL |
| 50 mM | 0.08 mL | 0.41 mL | 0.83 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mills Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature 2018 PMID: 29590092
Product Specific Notices for 4-Octyl itaconate
For research use only
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