3F8

Name: 3F8
Brand: Tocris Bioscience
SKU: 4083

Tocris Bioscience, part of Bio-Techne | Catalog # 4083

Citations (5)

COA / SDS

Potent and selective GSK-3β inhibitor

Discontinued Product

4083 has been discontinued. View all GSK-3 Inhibitors products.

Key Product Details

Description:	Potent and selective GSK-3β inhibitor
Chemical Name:	5-Ethyl-7,8-dimethoxy-1H-pyrrolo[3,4-c]isoquinoline-1,3(2H)-dione
Purity:	≥99% (HPLC)
Molecular Weight:	286.28

View Full Technical Details for 3F8

Technical Data
Citations

Biological Activity for 3F8

3F8 is a potent and selective GSK-3β inhibitor (IC₅₀ values are 34 and 304 nM in the presence of 10 and 100 μM ATP respectively).

Compound Libraries for 3F8

3F8 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for 3F8

M. Wt	286.28
Formula	C₁₅H₁₄N₂O₄
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	159109-11-2
PubChem ID	23829003
InChi Key	ULVWJFBHQIXEPE-UHFFFAOYSA-N
Smiles	O=C(NC3=O)C2=C3C1=CC(OC)=C(OC)C=C1C(CC)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for 3F8

References are publications that support the biological activity of the product.

Zou Benzo[e]isoindole-1,3-diones as potential inhibitors of glycogen synthase kinase-3 (GSK-3). Synthesis, kinase inhibitory activity, zebrafish phenotype, and modeling of binding mode. J.Med.Chem. 2010 PMID: 20030405
Zhong Characterization and development of novel small-molecules inhibiting GSK3 and activating wnt signaling. Mol.Biosyst. 2009 PMID: 19823752

3F8

Tocris Bioscience, part of Bio-Techne | Catalog # 4083

Key Product Details

Biological Activity for 3F8

Compound Libraries for 3F8

Technical Data for 3F8

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for 3F8

Product Documents for 3F8

COA

Certificate of Analysis

SDS

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