3-Bromocytisine

Name: 3-Bromocytisine
Brand: Tocris Bioscience
SKU: 3549

Tocris Bioscience, part of Bio-Techne | Catalog # 3549

Citations (3)

COA / SDS

Potent α4β4, α4β2 and α7 nAChR agonist

Key Product Details

Description:	Potent α4β4, α4β2 and α7 nAChR agonist
Chemical Name:	(1R,5S)-9-Bromo-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
Purity:	≥98% (HPLC)
Molecular Weight:	269.14

View Full Technical Details for 3-Bromocytisine

Technical Data
Citations

Biological Activity for 3-Bromocytisine

3-Bromocytisine is a potent agonist of α4β4, α4β2 and α7 nACh receptors (IC₅₀ values are 0.28, 0.30 and 31.6 nM respectively). Displays different effects on high (HS) and low (LS) ACh sensitivity α4β2 nAChRs (EC₅₀ values are 0.008 and 0.05 μM respectively).

Technical Data for 3-Bromocytisine

M. Wt	269.14
Formula	C₁₁H₁₃BrN₂O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	207390-14-5
PubChem ID	15519735
InChi Key	DWDCLEHDNICBMI-JGVFFNPUSA-N
Smiles	O=C2N1C[C@@]([H])(C3)CNC[C@@]([H])3C1=CC=C2Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 3-Bromocytisine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	26.91	100
	DMSO	26.91	100

Preparing Stock Solutions for 3-Bromocytisine

The following data is based on the product molecular weight 269.14.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.72 mL	18.58 mL	37.16 mL
5 mM	0.74 mL	3.72 mL	7.43 mL
10 mM	0.37 mL	1.86 mL	3.72 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

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Reconstitution Calculator

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References for 3-Bromocytisine

References are publications that support the biological activity of the product.

Moroni α₄β₂ nicotinic receptors with high and low acetylcholine sensitivity: pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine. Mol.Pharmacol. 2006 PMID: 16720757
Houlihan Activity of cytisine and its brominated isoteres on recombinant human α7, α4β2 and α4β4 nicotinic acetylcholine receptors. J.Neurochem. 2001 PMID: 11553677