3,5-DHBA

Name: 3,5-DHBA
Brand: Tocris Bioscience
SKU: 4599

Tocris Bioscience, part of Bio-Techne | Catalog # 4599

Citations (5)

COA / SDS

Selective HCA1 agonist

Key Product Details

Description:	Selective HCA₁ agonist
Chemical Name:	3,5-Dihydroxybenzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	154.12

View Full Technical Details for 3,5-DHBA

Technical Data
Citations

Biological Activity for 3,5-DHBA

3,5-DHBA is a selective agonist of hydroxycarboxylic acid receptor 1 (HCA₁, also known as GPR81) (EC₅₀ ~150 μM). Inhibits lipolysis in wild-type mouse adipocytes. Displays minimal activity at HCA₂ (at concentrations >10 mM) and no activity at HCA₃, free fatty acid receptor (FFAR) 2 or FFAR3.

Technical Data for 3,5-DHBA

M. Wt	154.12
Formula	C₇H₆O₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	99-10-5
PubChem ID	7424
InChi Key	UYEMGAFJOZZIFP-UHFFFAOYSA-N
Smiles	OC1=CC(O)=CC(C(O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 3,5-DHBA

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	15.41	100
	DMSO	15.41	100

Preparing Stock Solutions for 3,5-DHBA

The following data is based on the product molecular weight 154.12.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.49 mL	32.44 mL	64.88 mL
5 mM	1.30 mL	6.49 mL	12.98 mL
10 mM	0.65 mL	3.24 mL	6.49 mL
50 mM	0.13 mL	0.65 mL	1.30 mL

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Reconstitution Calculator

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References for 3,5-DHBA

References are publications that support the biological activity of the product.

Liu 3,5-dihydroxybenzoic acid, a specific agonist for hydroxycarboxylic acid 1, inhibits lipolysis in adipocytes. J.Pharmacol.Exp.Ther. 2012 PMID: 22434674