(2R,4R)-APDC

Name: (2 R ,4 R )-APDC
Brand: Tocris Bioscience
SKU: 1208

Tocris Bioscience, part of Bio-Techne | Catalog # 1208

Citations (12)

COA / SDS

Highly selective group II agonist

Key Product Details

Description:	Highly selective group II agonist
Chemical Name:	(2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylate
Purity:	≥98% (HPLC)
Molecular Weight:	174.16

View Full Technical Details for (2R,4R)-APDC

Technical Data
Citations

Biological Activity for (2R,4R)-APDC

(2R,4R)-APDC is a highly selective and relatively potent group II metabotropic glutamate receptor agonist. EC₅₀ values are 0.4, 0.4, > 100, > 100, > 300 and > 300 μM for human mGlu₂, mGlu₃, mGlu₁, mGlu₅, mGlu₄ and mGlu₇ receptors respectively. Centrally active following systemic administration in vivo.

Licensing Information

Sold with the permission of Eli Lilly and Company

Technical Data for (2R,4R)-APDC

M. Wt	174.16
Formula	C₆H₁₀N₂O₄
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	169209-63-6
PubChem ID	5310984
InChi Key	XZFMJVJDSYRWDQ-AWFVSMACSA-N
Smiles	N[C@]1([C@](O)=O)C[C@H]([C@](O)=O)NC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (2R,4R)-APDC

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions for (2R,4R)-APDC

The following data is based on the product molecular weight 174.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.74 mL	28.71 mL	57.42 mL
5 mM	1.15 mL	5.74 mL	11.48 mL
10 mM	0.57 mL	2.87 mL	5.74 mL
50 mM	0.11 mL	0.57 mL	1.15 mL

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Reconstitution Calculator

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References for (2R,4R)-APDC

References are publications that support the biological activity of the product.

Schoepp Selective inhibition of forskolin-stimulated cyclic AMP formation in rat hippocampus by a novel mGluR agonist, 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate. Neuropharmacology 1995 PMID: 8532165
Schoepp Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology 1999 PMID: 10530808
Monn Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase. J.Med.Chem. 1996 PMID: 8709133