2-Hydroxysaclofen

Name: 2-Hydroxysaclofen
Brand: Tocris Bioscience
SKU: 0245

Tocris Bioscience, part of Bio-Techne | Catalog # 0245

Citations (47)

COA / SDS

Selective GABAB antagonist; more potent than Saclofen (Cat. No. 0246)

Key Product Details

Description:	Selective GABA_B antagonist; more potent than Saclofen (Cat. No. 0246)
Chemical Name:	(RS)-3-Amino-2-(4-chlorophenyl)-2-hydroxypropyl-sulfonic acid
Molecular Weight:	265.71

View Full Technical Details for 2-Hydroxysaclofen

Technical Data
Citations

Biological Activity for 2-Hydroxysaclofen

2-Hydroxysaclofen is a selective antagonist at GABA_B receptors.

Technical Data for 2-Hydroxysaclofen

M. Wt	265.71
Formula	C₉H₁₂ClNO₄S
Storage	Store at RT
CAS Number	117354-64-0
PubChem ID	1564
InChi Key	WBSMZVIMANOCNX-UHFFFAOYSA-N
Smiles	NCC(O)(CS(O)(=O)=O)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 2-Hydroxysaclofen

	Solvent	Max Conc. mM
Solubility
	water	5
	1eq. NaOH	100

Preparing Stock Solutions for 2-Hydroxysaclofen

The following data is based on the product molecular weight 265.71.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.76 mL	18.82 mL	37.64 mL
5 mM	0.75 mL	3.76 mL	7.53 mL
10 mM	0.38 mL	1.88 mL	3.76 mL
50 mM	0.08 mL	0.38 mL	0.75 mL

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Reconstitution Calculator

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References for 2-Hydroxysaclofen

References are publications that support the biological activity of the product.

Kerr 2-Hydroxysaclofen: an improved antagonist at central and peripheral GABA_B receptors. Neurosci.Lett. 1988 PMID: 2847092
Curtis Baclofen antagonism by 2-hydroxysaclofen in the cat spinal cord. Neurosci.Lett. 1988 PMID: 2847093