193 D7
Tocris Bioscience, part of Bio-Techne | Catalog # 8167
JMJD1C inhibitor
Product Description
193 D7 is a histone demethylase JMJD1C inhibitor (IC50 = 0.59 μM in in vitro demethylation assay). In vivo, 193 D7 suppresses tumor by targeting intratumoral Treg cells in mice tumor models. 193 D7 is orally bioavailable.Product Specifications
Molecular Weight
317.36
Formula
C16H15NO4S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
8-Benzoyl-2,3,6,7-tetrahydro-5-oxo-5H-thiazolo[3,2-a]pyridine-6-acetic acid
CAS Number
861224-48-8
PubChem ID
12182298
InChI Key
DZLRINQZFUBGSQ-UHFFFAOYSA-N
SMILES
O=C(CC1C(N2C(SCC2)=C(C1)C(C3=CC=CC=C3)=O)=O)O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.74 | 100 | |
| Ethanol | 6.35 | 20 |
Preparing Stock Solutions
for 193 D7
The following data is based on the product molecular weight 317.36
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.15 mL | 15.75 mL | 31.51 mL |
| 5 mM | 0.63 mL | 3.15 mL | 6.30 mL |
| 10 mM | 0.32 mL | 1.58 mL | 3.15 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.63 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Long Targeting JMJD1C to selectively disrupt tumor Treg cell fitness enhances antitumor immunity. Nat.Immunol. 2024 PMID: 38356061
Product Specific Notices for 193 D7
For research use only
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