1-EBIO
Tocris Bioscience, part of Bio-Techne | Catalog # 1041
Epithelial KCa channel activator
Discontinued Product
1041 has been discontinued.
View all Ca2+-Activated Potassium Channel Activators products.
Key Product Details
Description
Epithelial KCa channel activator
Product Description
1-EBIO is an activator of epithelial KCa channels, stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. Promotes embryonic stem cell (ESC) differentiation into cardiomyocytes.Product Specifications
Molecular Weight
162.19
Formula
C9H10N2O
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
1-Ethyl-2-benzimidazolinone
CAS Number
10045-45-1
PubChem ID
82320
InChI Key
CXUCKELNYMZTRT-UHFFFAOYSA-N
SMILES
CCN1C(=O)NC2=C1C=CC=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 16.22 | 100 | |
| Ethanol | 16.22 | 100 |
Preparing Stock Solutions
for 1-EBIO
The following data is based on the product molecular weight 162.19
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.17 mL | 30.83 mL | 61.66 mL |
| 5 mM | 1.23 mL | 6.17 mL | 12.33 mL |
| 10 mM | 0.62 mL | 3.08 mL | 6.17 mL |
| 50 mM | 0.12 mL | 0.62 mL | 1.23 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kleger Modulation of calcium-activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker-like cells. Circulation. 2010 PMID: 20956206
- Devor Modulation of Cl- secretion by benzimidazolones. I. Direct activation of a Ca2+ - dependent K+ channel. Am.J.Physiol. 1996 PMID: 8944721
- Kusama Reduced hyperpolarisation in endothelial cells of rabbit aortic value following chronic nitroglycerine administration. Br.J.Pharmacol. 2005 PMID: 16056232
- Ayotunde and Adeagbo 1-Ethyl-2-benzimidazolinone stimulates endothelial KCa channels and nitric oxide formation in rat mesenteric vessels. Eur.J.Pharmacol. 1999 PMID: 10497901
Product Specific Notices for 1-EBIO
For research use only
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