1-Deazaadenosine

Name: 1-Deazaadenosine
Brand: Tocris Bioscience
SKU: 4488

Tocris Bioscience, part of Bio-Techne | Catalog # 4488

Citations (2)

COA / SDS

Adenosine deaminase inhibitor

Key Product Details

Description:	Adenosine deaminase inhibitor
Chemical Name:	3-β-D-Ribofuranosyl-3H-imidazo[4,5-b]pyridin-7-amine
Purity:	≥98% (HPLC)
Molecular Weight:	266.25

View Full Technical Details for 1-Deazaadenosine

Technical Data
Citations

Biological Activity for 1-Deazaadenosine

1-Deazaadenosine is an inhibitor of adenosine deaminase (K_i = 0.66 μM). Demonstrates antitumor activity in a range of leukemia cell lines.

Technical Data for 1-Deazaadenosine

M. Wt	266.25
Formula	C₁₁H₁₄N₄O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	14432-09-8
PubChem ID	159738
InChi Key	NVUDDRWKCUAERS-PNHWDRBUSA-N
Smiles	NC1=C2C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)C=N2)=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 1-Deazaadenosine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	6.66	25

Preparing Stock Solutions for 1-Deazaadenosine

The following data is based on the product molecular weight 266.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	15.02 mL	75.12 mL	150.23 mL
1.25 mM	3.00 mL	15.02 mL	30.05 mL
2.5 mM	1.50 mL	7.51 mL	15.02 mL
12.5 mM	0.30 mL	1.50 mL	3.00 mL

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Reconstitution Calculator

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References for 1-Deazaadenosine

References are publications that support the biological activity of the product.

Cristalli Improved synthesis and antitumor activity of 1-deazaadenosine. J.Med.Chem. 1987 PMID: 3625714
Cristalli Adenosine deaminase inhibitors: Structure-activity relationships in 1-deazaadenosine and erythro-9-(2-hydroxy-3-nonyl)adenine analogues. Drug Dev.Res.