Simple Plex Discovery Control for Human PD-L2
ProteinSimple, part of Bio-Techne | Catalog # 898738
Control for use with Human PD-L2 Simple Plex Assay Cartridge Kit
Key Product Details
Species
Human
Product Summary for Simple Plex Discovery Control for Human PD-L2
INTENDED USE AND DESCRIPTION: For use a quantitative control for the determination of human PD-L2 concentrations in biological fluids. Controls are supplied lyophilized. Please refer to the lot specific certificate of analysis and Simple Plex Lyophilized Quality Control product insert for additional information.
Formulation, Preparation, and Storage
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
• Store lyophilized controls at 2-8 °C. Lyophilized controls are stable for up to 12 months from date of receipt.
• Reconstituted controls are stable for up to 6 months from date of preparation when stored at ≤ -70 °C. Storage at -20° C is not recommended.
• Individual frozen aliquots of low and high controls are designed as single-use entities. Thaw directly before use and discard any remaining volume.
• Reconstituted controls are stable for up to 6 months from date of preparation when stored at ≤ -70 °C. Storage at -20° C is not recommended.
• Individual frozen aliquots of low and high controls are designed as single-use entities. Thaw directly before use and discard any remaining volume.
Background: PD-L2/B7-DC
PD-L2 (Programmed Death Ligand 2), also known as B7-DC and butyrophilin-like protein, is a transmembrane protein expressed on dendritic cells, subsets of activated CD4+ and CD8+ T cells, and memory B cells that differentiate into plasma cells. At inflammatory sites, PD-L2 is upregulated on synoviocytes, infiltrating macrophages, dendritic cells, and airway epithelial cells. PD-L2, along with B7-H1/PD-L1, binds to T cell PD-1 where it promotes IFN-gamma production and CD40 Ligand upregulation while inhibiting IL-4 production. In addition, PD-L2 binds to RGM-B on macrophages and alveolar epithelial cells, supporting respiratory immune tolerance. In asthma, PD-L2 suppresses IL-5 and IL-13 production, promotes IL-12 production by dendritic cells, and supports allergen-induced airway hyper-responsiveness and mucus production.
Long Name
Programmed Death-1 Ligand-2
Alternate Names
B7-DC, Butyrophilin-like Protein, CD273, PDCD1LG2, PDL2
Gene Symbol
PDCD1LG2
Additional PD-L2/B7-DC Products
Product Documents for Simple Plex Discovery Control for Human PD-L2
Product Specific Notices for Simple Plex Discovery Control for Human PD-L2
For research use only
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