Simple Plex Discovery Control for Human beta-Defensin 2

INTENDED USE AND DESCRIPTION: For use a quantitative control for the determination of human Beta Defensin-2 concentrations in biological fluids. Controls are supplied lyophilized. Please refer to the lot specific certificate of analysis and Simple Plex Lyophilized Quality Control product insert for additional information.

Defensins are members of a family of microbicidal and cytotoxic peptides produced by neutrophils. They are classified into alpha-, beta-, and theta-defensins based on their sizes and intramolecular disulfide bond patterns. Human beta-Defensin 2 (BD-2; aa 24 - 64) also known as defensin beta 2 (DEFB-2), is a secreted, 41 amino acid residue anti-microbial protein belonging to the defensin family. Mature defensins are cationic proteins with three intramolecular disulfides and a characteristic triple-stranded beta-sheet. Human beta-Defensin 2 expression is induced by inflammatory signals in multiple tissues, including airway epithelial cells and keratinocytes. At the amino acid sequence level, human beta-Defensin 2 shares 98% and 51% homology with the proteins from rhesus monkey and rat, respectively.