Simple Plex Control for Human TIMP-1

Name: Simple Plex Control for Human TIMP-1
Brand: ProteinSimple
SKU: 898104

ProteinSimple, part of Bio-Techne | Catalog # 898104

Product Datasheet / COA

Control for use with Human TIMP-1 Simple Plex Cartridge Kit

Key Product Details

Technical Data
Citations

Summary for Simple Plex Control for Human TIMP-1

INTENDED USE AND DESCRIPTION: For use a quantitative control for the determination of human TIMP-1 concentrations in biological fluids. Controls are supplied lyophilized. Please refer to the lot specific certificate of analysis and Simple Plex Lyophilized Quality Control product insert for additional information.

TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.

Product Specifications for Simple Plex Control for Human TIMP-1

Species	Human
Applications	Control, Simple Plex Automated Immunoassay
Source	N/A

Preparation & Storage

Shipping Conditions

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Storage

• Store lyophilized controls at 2-8 °C. Lyophilized controls are stable for up to 12 months from date of receipt.
• Reconstituted controls are stable for up to 6 months from date of preparation when stored at ≤ -70 °C. Storage at -20° C is not recommended.
• Individual frozen aliquots of low and high controls are designed as single-use entities. Thaw directly before use and discard any remaining volume.

Background: TIMP-1

Item	Value
Long Name	Tissue Inhibitors of Metalloproteinases 1
Entrez Gene IDs	7076 (Human); 21857 (Mouse); 116510 (Rat)
Alternate Names	CLGI, Collagenase inhibitor, EPATIMP-1, EPO, Erythroid-potentiating activity, FLJ90373, Fibroblast collagenase inhibitor, HCI, TIMP metallopeptidase inhibitor 1, TIMP-1, TIMP1, TIMPtissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, Tissue inhibitor of metalloproteinases 1, collagenase inhibitor), erythroid potentiating activity, metalloproteinase inhibitor 1

Product Documents for Simple Plex Control for Human TIMP-1

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