Non-Human Primate TIMP-2 Cartridge
ProteinSimple, part of Bio-Techne | Catalog # SPCKB-NP-011336
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Key Product Details
Assay Length
Sample Type & Volume Required Per Well*
Sensitivity
Assay Range
Non-Human Primate TIMP-2 Cartridge Summary
*The Sample Volume represented is based on the amount of sample incorporated into the reaction after taking into account the assay's minimum required dilution for a given matrix. Serial dilution may be necessary to achieve some of the final sample volumes represented.
Compatible Instruments
Ella Automated Immunoassay System
Product Specifications
Assay Type
Format
Reactivity
Specificity
Cross-reactivity
Interference
Precision
Intra-Assay Precision (Precision within an assay) Each control was tested 16 times in one assay.
Inter-Assay Precision (Precision between assays) Replicates of each control were tested in multiple assays performed by at least three technicians using two lots of reagents.
EDTA Plasma, Heparin Plasma, Serum
| Intra-Assay Precision | Inter-Assay Precision | |||
|---|---|---|---|---|
| Sample | 1 | 2 | 1 | 2 |
| n | 16 | 16 | 47 | 47 |
| Mean (pg/mL) | 183 | 9932 | 167 | 10585 |
| Standard Deviation | 8.3 | 587 | 11.2 | 991 |
| CV% | 4.5 | 5.9 | 6.7 | 9.4 |
Recovery for Non-Human Primate TIMP-2 Cartridge
Recovery was not necessary as TIMP-2 shows 5 points of natural linearity.
Linearity
Samples containing and/or spiked with high concentrations of TIMP-2 were serially diluted with Sample Diluent to produce samples within the dynamic range of the assay.
Scientific Data Images for Non-Human Primate TIMP-2 Cartridge
Non-Human Primate TIMP-2 Ella Assay Standard Curve
Preparation and Storage
Shipping
Stability & Storage
Background: TIMP-2
TIMP-2 (tissue inhibitor of metalloproteinases 2) is one of several TIMPs that form complexes with matrix metalloproteinases (MMPs) and inhibit their proteolytic activity. MMPs play an important role in many normal physiological processes such as embryonic development, morphogenesis, reproduction and tissue remodeling. They also participate in many pathological processes such as arthritis, cancer and cardiovascular disease. TIMP-2 binding to pro-MMP-2 is essential for the cell surface activation of pro-MMP-2 by active MMP-14 (MT1-MMP). TIMP-2 also suppresses EGF-mediated mitogenic signaling by short-circuiting EGF R activation.
Long Name
Alternate Names
Gene Symbol
Additional TIMP-2 Products
Product Documents for Non-Human Primate TIMP-2 Cartridge
Product Specific Notices for Non-Human Primate TIMP-2 Cartridge
For research use only